tag:blogger.com,1999:blog-8671697563173928351.comments2023-09-27T01:37:06.703-07:00progeria family circleUnknownnoreply@blogger.comBlogger3125tag:blogger.com,1999:blog-8671697563173928351.post-75564627418072577072012-08-22T20:55:38.512-07:002012-08-22T20:55:38.512-07:00This comment has been removed by a blog administrator.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8671697563173928351.post-46820126903099997052012-05-30T23:27:06.072-07:002012-05-30T23:27:06.072-07:00This comment has been removed by a blog administrator.adverse seohttps://www.blogger.com/profile/06693967044003645163noreply@blogger.comtag:blogger.com,1999:blog-8671697563173928351.post-73889326601283035762011-11-08T09:34:09.311-08:002011-11-08T09:34:09.311-08:00This approach has a good chance of leading to an e...This approach has a good chance of leading to an effective therapeutic. Here are the fundamental papers describing the oligo-mediated approach:<br /><br />Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science. 2006 May 19;312(5776):1059-63. Epub 2006 Apr 27. <br /><br />Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med. 2005 Apr;11(4):440-5. Epub 2005 Mar 6. <br /><br />Here's an introduction to the Morpholino oligos:<br /><br />http://en.wikipedia.org/wiki/MorpholinoJon Moultonhttps://www.blogger.com/profile/12699068470557850919noreply@blogger.com